Morphological changes in liver of wistar rats induced by Gold Kushta

Objective: To observe hepatic changes induced by Gold Kushta. In our study the histopathological effects of Kushta was seen in livers Wistar rats. Study Design: Experimental study. Setting: Department Pathology, Sahiwal Medical College, Sahiwal. Period: 1st July 2019 to 31st Dec 2019. Material & Method: Total 28 wistar rats 6 – 8 weeks age and weighing 200 250 grams which were then randomly divided into 4 groups each containing 7 The labelled as G I, II, III IV. These given preparations gold form kushta for a period weeks. pellets. Group I taken Control, II single dose 0.15 mg double 0.3mg on alternate days. IV BSA (bovine serum albumin) 75mg (250mg/kg body wt) at start experiment 0.3 Histopathological lobules, sinusoids, kupffer cells central veins Results: histological examination liver showed sinusoidal congestion vein congestion, apoptosis, necrosis hydropic degeneration common features. addition fatty degeneration, inflammation cell hyperplasia also few cases. observed all above except group serving control. More high inj. (Group IV). Conclusion: Thus, indigenous have detrimental over are thus hepatotoxic.